Abstractα/β barrels have an ill‐defined origin. Evidence exists which favours their divergent evolution from a common ancestral barrel and convergent evolution to a stable fold. However, recent sequence and structural information for the flavin oxidase/dehydrogenase family of barrel enzymes indicate that sub‐families of α/β barrels have evolved divergently. The modular fusion of barrel domains with core structures from other gene families has also contributed to the evolution of related but catalytically distinct enzyme molecules within each sub‐family of the flavin oxidases/dehydrogenases. (...) An analysis of the structures and sequences of the flavin oxidases/dehydrogenases has now enabled studies focusing on the evolutionary origins and modular assembly of this important family of proteins to be initiated. (shrink)

As the 20th century began, few effective therapies existed. This soon changed with major therapeutic discoveries turning the century into what has been called the golden age of therapeutics.1 The emphasis of most of these developments was on medicines for common disorders as they presented the greatest need. However, it also allowed pharmaceutical manufacturers to produce blockbuster drugs that provided a large return on investment. Rare disorders were overlooked because most are genetic in origin and scientific knowledge was lacking, making (...) it difficult to find treatments. The first genetic disorder with a therapy was phenylketonuria. The biochemist who proposed the first successful treatment in the 1950s was actively discouraged as phenylketonuria was genetic and ‘incurable’.2 Another reason was an absence of incentives to invest in developing medicines for which the return was limited, given the small numbers of potential patients. This changed from 1983 as several countries began introducing orphan drug policies, with Canada being a notable exception. As the millennium changed, some drugs for rare disorders were available, but the sequencing of the human genome in the early 2000s provided scientific knowledge to develop many more. The new therapies are often costly because they require millions, even billions, of dollars and years to develop, test and satisfy regulatory standards. …. (shrink)

A set of amino acid side chains that confer specificity for the coenzyme NADPH and the substrate glutathione in the flavoprotein disulphide oxidoreductase, glutathione reductase, has been identified. Systematic replacement of these amino acid residues in the coenzyme‐binding site switches the specificity of the enzyme from its natural strong preference for NADPH to a marked preference For NADH. The amino acids replaced all lie in a structural motif within the dinucleotide‐binding domain of the protein. Since this domain is a feature (...) common to most dehydrogenases (reductases) that use nicotinamide coenzymes, it may be that the coenzyme specificities of all such enzymes can be manipulated in this way. Similarly, amino acid residues involved in the selective recognition of trypanothione by trypanothione reductase, an enzyme related to glutathione reductase and exclusive to trypanosomatids, were identified. Suitable mutation of the corresponding residues in E. coli glutathione reductase switched its substrate specificity towards trypanothione. A better understanding of the substrate specificity of these enzymes could open up a route to the chemotherapy of trypanosomal infections. (shrink)

Recent events, such as the widespread acceptance of the book, Final Exit, show that the very foundation upon which all humane medical practice is ba sed is in danger of being replaced with ethical relativism. Cameron's book could very well be a rallying point for those in the profession who know something is wrong. Endorsed by C. Everett Koop.

This article examines four related aspects of Hegel's approach to the teaching of philosophy and to the philosophy of the teacher. Specifically, it highlights some of the views Hegel expressed on education in general whilst Rector of the Nuremberg gymnasium; describes his opinions on the place of philosophy within the school curriculum and the structure of the philosophy course which he designed for his pupils; examines the pedagogy which he employed in teaching his system of philosophy; and offers preliminary comments (...) on his insights into the contradictions which resist the abstract identity of the teacher. (shrink)

Cognitive science has always included multiple methodologies and theoretical commitments. The philosophy of cognitive science should embrace, or at least acknowledge, this diversity. Bechtel’s (2009a) proposed philosophy of cognitive science, however, applies only to representationalist and mechanist cognitive science, ignoring the substantial minority of dynamically oriented cognitive scientists. As an example of nonrepresentational, dynamical cognitive science, we describe strong anticipation as a model for circadian systems (Stepp & Turvey, 2009). We then propose a philosophy of science appropriate to nonrepresentational, dynamical (...) cognitive science. (shrink)

This paper offers a defence of sense-datum statements from A.J. Ayer’s perspective that represents a response to Quine’s naturalistic ontology. Starting with Quine’s “On What There Is” (1948), and the following “Symposium” of 1951, I argue that Ayer’s proposed method of establishing sense-datum statements in his “Symposium” piece, which challenges Quine’s ontology of physical objects, is not a viable alternative to Quine’s scientific naturalism. I argue that by taking a broadly intensional approach, Ayer can offer a response to Quine’s position. (...) More specifically, I contend that it is possible to form a distinctly non-scientific, epistemological account of sense-data by employing primitive “sensory predicates” within basic propositions. In terms of ontology, a technical ruling for “existence”, working alongside appropriate “meaning-rules”, legislates for basic sense-datum statements, thus distancing them from the regimented, extensionalised, stimulus meaning strategy indicative of Quine’s naturalistic ontology. (shrink)

"The extensive attention devoted to abortion has led Christians for too long to overlook much of the exploding bioethics agenda. Moreover, to focus only on 'issues' is to fail to address the profound changes taking place in the very nature of the medical profession. This book signals the commitment of the Center for Bioethics and Human Dignity to help expand the church's bioethical vision and to foster a more substantial Christian contribution to the public debate."--BOOK JACKET.Title Summary field provided by (...) Blackwell North America, Inc. All Rights Reserved. (shrink)

This book argues that the institutions of law, and the structures of legal thought, are to be understood by reference to a moral ideal of freedom or independence from the power of others. The moral value and justificatory force of law are not contingent upon circumstance, but intrinsic to its character. Doctrinal legal arguments are shaped by rival conceptions of the conditions for realization of the idea of law. In making these claims, the author rejects the viewpoint of much contemporary (...) legal theory, and seeks to move jurisprudence closer to an older tradition of philosophical reflection upon law, exemplified by Hobbes and Kant. Modern analytical jurisprudence has tended to view these older philosophies as confused precisely in so far as they equate an understanding of law's nature with a revelation of its moral basis. According to most contemporary legal theorists, the understanding and analysis of existing institutions is quite distinct from any enterprise of moral reflection, but the relationship between ideals and practices is much more intimate than this approach would suggest. Some institutions can be properly understood only when they are viewed as imperfect attempts to realize moral or political ideals; and some ideals can be conceived only by reference to their expression in institutions. (shrink)

A well-worn French proverb pronounces ‘tout comprendre c’est tout pardonner’ (‘to understand all is to forgive all’). Is forgiveness the inevitable consequence of social scientific understanding of the actions and lives of perpetrators of serious wrongdoing? Do social scientific explanations provide excuses or justifications for the perpetrators of the actions that the explanations purport to explain? In this essay, I seek clarification of these intertwined explanatory and moral questions.

What's Wrong with Rights? argues that contemporary rights-talk obscures the importance civic virtue, military effectiveness and the democratic law legitimacy. It draws upon legal and moral philosophy, moral theology, and court judgments. It spans discussions from medieval Christendom to contemporary debates about justified killing.

In the last twenty years a critique of the idea of a right as the property of an individual subject has been articulated by some influential Anglican theologians – Joan Lockwood O’Donovan, Oliver O’Donovan and John Milbank. Their objections are considerably based on an argument about intellectual history. Broadly pursuing an intellectual trajectory first set by Leo Strauss and C. B. Macpherson, these theologians think that the very concept of a ‘subjective right’ is tied, certainly historically but perhaps also logically, (...) to modern, Hobbesian social contract theory, and therefore to radical individualism and moral subjectivism. Therefore, they think that to affirm individual subjective rights is to exclude a larger objective order of moral right, and to undermine the authority of the claim of social obligation. Against this critique, this article, first, argues that a morally realist conception of subjective rights prevailed before Hobbes, and continued to prevail long afterwards. Second, the article proceeds to refute Ernest Fortin’s thesis that Hobbes came to dominate modern rights-talk through John Locke. Finally, it suggests that the contemporary detachment of the concept of subjective rights from a larger context of objective moral right has more plausible and more proximate roots in twentieth century philosophical and cultural developments. (shrink)

During the past four decades, the Netherlands played a leading role in the debate about euthanasia and assisted suicide. Despite the claim that other countries would soon follow the Dutch legalization of euthanasia, only Belgium and the American state of Oregon did. In many countries, intense discussions took place. This article discusses some major contributions to the discussion about euthanasia and assisted suicide as written by Nigel Biggar, Arthur J. Dyck, Neil M. Gorsuch, and John Keown. They share a (...) concern that legalization will undermine a society's respect for the inviolability and sanctity of life. Moreover, the Report of the House of Lords Select Committee on the Assisted Dying for the Terminally Ill Bill is analyzed. All studies use ethical, theological, philosophical, and legal sources. All these documents include references to experiences from the Netherlands. In addition, two recent Dutch documents are analyzed which advocate further liberalization of the Dutch euthanasia practice, so as to include infants and elderly people "suffering from life". (shrink)

I Am Dynamite ignites an alternative theory of the self and will, wrapped up in a combustible assault upon scholarly convention. Asking why the real effort of constructing and living within an identity is so often overlooked, it examines the subjective experience of existing in the world, with the power to define and transform oneself. Considering the trials and triumphs of five very different modern subjects--Primo Levi, Ben Glaser, Stanley Spencer, Rachel Silberstein and Friedrich Nietzsche--Nigel Rapport asks: can consciousness (...) of being a self in the world enable control over one's life within it? Calling for a renewed appreciation of the extraordinary within us all, this richly inventive work seeks to restore knowledge to its essential practical and moral aims--aiding and informing the lives we actually live. (shrink)

This commentary argues that Donna Haraway’s still remarkable ‘Manifesto for Cyborgs’ provided one of the first windows on the invention of a different kind of world, one in which environments figure and bodily registers expand. In her attention to bioscience she was clearly one of the first to remark on these developments. But, or so I argue, she may have underestimated their generality and their grip, not least because of the comparatively light imprint of the economy and space to be (...) found in her work. (shrink)

This article explores the notion of ‘perfect’ money that Simmel introduces in The Philosophy of Money. Its aim is twofold: first, to connect this idea to his more general arguments about the nature of society and the ambivalence of modernity, and, second, to assess its relevance for contemporary debates about the future of money, especially following the global financial crisis. I argue that Simmel’s concept of perfect money can be understood as utopian in two senses, conceptual and ethical, that correspond (...) to the two interpretations he develops, in Soziologie, of the idea of a perfect society. This sheds light on an aspect of Simmel’s writings that has attracted relatively little attention, namely his views on the relationship between money and socialism. Characterizing this relationship as a ‘formal affinity’, his remarks resonate with a long tradition of thought on monetary utopias that aim not for the abolition of money but its radical transformation as a means of improving society. This tradition is coming to the fore once again today, as the financial crisis has given new impetus to constructing forms of money – for example, LETS, Time Dollars, mutual credit, peer-to-peer lending and digital currencies such as Bitcoin – that provide viable alternatives to big banks. Understood in conjunction with his account of the ‘tragedy’ of individualism in modernity, such resonances demonstrate the enduring relevance of Simmel’s work to the empirical and theoretical investigation of money. (shrink)

This book offers a fresh and up-to-date account of the ethical thought of Karl Barth, one of the twentieth century's greatest theologians. In it, the author seeks to recover Barth's ethics from some widespread misunderstandings, and also presents a picture of it as a whole. Drawing on recently published sources, Biggar construes the ethics of the Church Dogmatics as it might have been had Barth lived to complete it. However, The Hastening that Waits is more than apology and description. For (...) it recommends to contemporary Christian ethics the theological rigor with which Barth expounds the good life in terms of the living presence of God-in-Christ to his creatures; his conception of right human action as that which is able to hasten in the service of humanity precisely by waiting prayerfully upon God; and his discriminate openness to moral wisdom outside the Christian church. Among particular topics treated are: the concepts of human freedom and of created moral order; moral norms and their relation to individual vocation; the relative ethical roles of the Bible, the Church, philosophy, and empirical science; moral character and its formation; and the problem of war. (shrink)

Introduction : the provocation of Levinas -- Being's other -- "Would you like to do a bit of theology?" : Levinas and theological turn -- The disturbance of theology -- Preferring the shadows : the "little faith" of Israel -- The return of God?

Modern western political thought revolves around globality, focusing on the partitioning and the connecting up of the earth’s surface. But climate change and the Anthropocene thesis raise pressing questions about human interchange with the geological and temporal depths of the earth. Drawing on contemporary earth science and the geophilosophy of Deleuze and Guattari, this article explores how geological strata are emerging as provocations for political issue formation. The first section reviews the emergence – and eventual turn away from – concern (...) with ‘revolutions of the earth’ during the 18th- and 19th-century discovery of ‘geohistory’. The second section looks at the subterranean world both as an object of ‘downward’ looking territorial imperatives and as the ultimate power source of all socio-political life. The third section weighs up the prospects of ‘earth system governance’. The paper concludes with some general thoughts about the possibilities of ‘negotiating strata’ in more generative and judicious ways. (shrink)

This article examines four related aspects of Hegel's approach to the teaching of philosophy and to the philosophy of the teacher. Specifically, it highlights some of the views Hegel expressed on education in general whilst Rector of the Nuremberg gymnasium; describes his opinions on the place of philosophy within the school curriculum and the structure of the philosophy course which he designed for his pupils; examines the pedagogy which he employed in teaching his system of philosophy; and offers preliminary comments (...) on his insights into the contradictions which resist the abstract identity of the teacher. (shrink)

Talk of “essences” has, since Saul Kripke and Hilary Putnam, gained significant currency in contemporary philosophy. It is no longer unfashionable to talk about the essence of this or that (natural) kind, and as such we now find a variety of brands of essentialism on the market including B.D. Ellis’s scientific essentialism, David Oderberg’s real Essentialism, Alexander Bird’s dispositional essentialism, and the contemporary essentialism of Kripke and Putnam. -/- Almost all these brands of essentialism share a particular gloss on Locke’s (...) famous objection to Aristotle that natural kinds are demarcated by nominal essences not real essences. Thus Oderberg claims that ‘Empiricists take [real] essences to be paradigmatically unobservable’ and that this ‘objection goes back at least to John Locke’ (Oderberg 2007: 21). Bird, presenting his dispositional essentialism, defines a notion of “being” as ‘the reverse of Locke’s definition of essence’ which he takes to be ‘the being of any thing, whereby it is what it is’ (Bird 2007: 100). Joseph LaPorte, discussing nominal and real essences, claims that ‘Kripke and Putnam seem to affirm something more substantive: that biological kinds have “real essences” in Locke’s terminology’ (LaPorte 2004: 49). Even avowed anti-essentialists such as John Dupré sanction the standard criticism of Locke that his scepticism about the knowability of real essences was ‘premature’, and claim that ‘genuine natural kinds provide the extensions of many terms of natural language, where these natural kinds are determined by true Lockean real essences’ (Dupré 1993: 22). -/- All of these essentialisms (even Dupré’s anti-essentialism) are wrong about Locke. Oderberg is wrong to claim that Locke thought that real essences were paradigmatically unobservable; Bird is wrong to think that Locke’s notion of essence is the being of anything whereby it is what it is; LaPorte is wrong to think that Kripke and Putnam are talking about Lockean real essences (although so are Kripke and Putnam); and Dupré is wrong to think that genuine natural kinds (if by genuine he means objective or mind-independent) are determined but true Lockean real essences . -/- The mistake stems from a standard, but ultimately incorrect, interpretation of Locke’s discussion of essences in An Essay Concerning Human Understanding . This mistaken interpretation (Lowe 1995, 2006, Von Leyden 1973, Wiggins 1974) takes Locke to mean, by “real essence”, the Aristotelian notion i.e. ‘the very being of anything, whereby it is what it is’ (Essay III.iii.15), and interprets his objection as epistemological: we cannot come to know what real essences are, and therefore they cannot figure in our classifications of things into kinds. -/- This paper will present and defend the following two claims: i) that Locke’s notion of “real essence” is not the Aristotelian notion, and ii) that Locke’s objection to the Aristotelian notion was not merely epistemological. The first claim can be defended by presenting and applying Vienne’s (1993) terminological revision. Vienne argues that Locke did not introduce a dichotomy between real and nominal essence, but a trichotomy between real essence, nominal essence and real constitution. This terminological revision will be employed to highlight where ambiguous uses of the phrase “real essence” have caused some serious misunderstandings of Locke’s philosophy. The second claim (steering Locke around what is the classic objection to his thesis) can be defended by presenting a novel way of splitting up Locke’s objections to the Aristotelian notion of essence. The analysis will show that Locke’s anti-essentialism is still in good shape, and of contemporary significance. (shrink)

Men and women report having significantly different numbers of sexual partners, which is impossible in a large sample. Schmitt's target article is no exception. This focuses discussion on the nature of the samples, their heterogeneity, and the locale they are drawn from. Further, we query how humans determine, for example, sex ratio, in the context of large numbers.

The so-called “problem” of structure and agency is clearly related to the philosophical problem of free will and determinism, yet the central philosophical issues are not well understood by theorists of structure and agency in the social sciences. In this article I draw a map of the available stances on the metaphysics of free will and determinism. With the aid of this map the problem of structure and agency will be seen to dissolve. The problem of structure and agency is (...) sustained by a failure to distinguish between metaphysical and empirical senses of the relation between social structure and individual agency. The ramifications of this distinction are illustrated via a case study of competing explanations of perpetrator behavior in Christopher Browning’s and Daniel Goldhagen’s studies of the German Order Police in the Holocaust. (shrink)

In the recent and not-too-distant past many of our parents, grandparents and forbears believed that a person’s skin colour and physiognomy, gender, or sexuality licensed them being regarded and treated in ways that are now widely recognised as blatantly unjust, disrespectful, cruel and brutal. But the nineteenth, twentieth, and twenty-first centuries have hosted a series of radical changes in attitudes, beliefs, behaviour and institutionalised practices with regard to the fundamental moral equality of what were once seen as different “kinds of (...) people.” This paper explores the social structure of such “moral revolutions,” via the Wittgensteinian- and Kuhnian- inspired concepts moral perception, moral certainty, normal morality, and moral paradigm. (shrink)

Dating back to the very beginning of our knowledge of the events that constituted the Holocaust, some historians, social scientists, philosophers, theologians and public intellectuals argue that it was a unique historical, or even trans-historical, event. The aim of this article is to clarify what the uniqueness question should be about and to ascertain whether there are good reasons for judging that the Holocaust is unique. It examines the core meanings of ‘unique’ that feature in the literature and identifies which (...) of these is most apt for considering the possible uniqueness of the Holocaust. It then works out what it would take for the Holocaust to be unique in the appropriately rigorous sense, which is facilitated by inquiring into the nature of genocide. The key question turns on the relation of the Holocaust to genocide: was the Holocaust more than, or different from, genocide? (shrink)

The received understanding of Winch’s critique of social science is that he propounded a radically relativist, anti-explanatory and a-critical conception of the legitimate task of ‘social studies’. This conception is presumed to be predicated upon an extension of Wittgenstein’s critique of philosophy. I argue, against this view, that Winch reads Wittgenstein through a Kantian framework, and that in fact he advanced a rigorously essentialist and universalist picture of ‘social phenomena’. It is Winch’s underlying Kantian metaphysics that has made his ideas (...) attractive to contemporary architects of critical social theory, such as Giddens and Habermas. However, in opposition to the latter, and in spite of his Kantianism, I discern in Winch a genuinely critical attitude towards social understanding. (shrink)

Psychoanalytic accounts offer a mix of reasons and causes to explain action. Adolf Grünbaum argues that these fail to be proper explanations because they are neither justified by inductively established laws, nor fit the standard form of rational explanation, the belief-plus-desire-yields-action structure of the practical syllogism. Grünbaum accepts rational explanation as cogent and transparently causal because, he asserts, reasons are causes. Yet he omits to show how they can be, especially in the face of the apparent fact that reasons, being (...) defined in terms of their propositional content, cannot be causes. Clarifying the position of psychoanalytic explanation does involve seeing it and rational explanation as similarly causal. This requires a realist analysis showing how reasons may be understood, not as defined in terms of their propositional contents or objects, but as states of persons caused by entering into relations with situations, and how reasoning is a causal process. Freud's philosophical intuitions on this were correct. His much criticized metapsychology offers a causal account of motives defined by source, not object, and sketches an account of the way these cause action in interaction with external situations. 2012 APA, all rights reserved). (shrink)

This araticle examines elements of Jean-François Lyotard’s paradoxical negotiations with aesthetic experiences in order to characterize his critical involvement with discursivized forms of knowing and explanation. These elements are offered as salient and salutary correctives to the symmetrical dogmas of disenchanting naturalisms and culturalisms currently programming typical misprisions of the aesthetic. Lyotard’s 1971 Discourse, Figure, as well as some of his later writings on visual art and artists, are not interpretatively integrated here but instead explored in terms of an anti-discursive (...) logic that actually animates what appear to be their own anti-aesthetic commitments and conclusions. The article tracks the ambivalent, but persistent, role that perception, art-medium and sensate experience play in Lyotard’s efforts to see beyond them. This result impacts not only on the kinds of ‘demystification’ his work should be seen to espouse, but on that pervasive pseudo-category itself. (shrink)

Alice Crary claims that “the standard view of the bearing of Wittgenstein's philosophy on ethics” is dominated by “inviolability interpretations”, which often underlie conservative readings of Wittgenstein. Crary says that such interpretations are “especially marked in connection with On Certainty”, where Wittgenstein is represented as holding that “our linguistic practices are immune to rational criticism, or inviolable”. Crary's own conception of the bearing of Wittgenstein's philosophy on ethics, which I call the “intrinsically-ethical reading”, derives from the influential New Wittgenstein school (...) of exegesis, and is also espoused by James Edwards, Cora Diamond, and Stephen Mulhall. To my eyes, intrinsically-ethical readings present a peculiar picture of ethics, which I endeavour to expose in Part I of the paper. In Part II I present a reading of On Certainty that Crary would call an “inviolability interpretation”, defend it against New Wittgensteinian critiques, and show that this kind of reading has nothing to do with ethical or political conservatism. I go on to show how Wittgenstein's observations on the manner in which we can neither question nor affirm certain states of affairs that are fundamental to our epistemic practices can be fruitfully extended to ethics. Doing so sheds light on the phenomenon that I call “basic moral certainty”, which constitutes the foundation of our ethical practices, and the scaffolding or framework of moral perception, inquiry, and judgement. The nature and significance of basic moral certainty will be illustrated through consideration of the strangeness of philosophers' attempts at explaining the wrongness of killing. (shrink)

This paper challenges the notion that Bitcoin is ‘trust-free’ money by highlighting the social practices, organizational structures and utopian ambitions that sustain it. At the paper's heart is the paradox that if Bitcoin succeeds in its own terms as an ideology, it will fail in practical terms as a form of money. The main reason for this is that the new currency is premised on the idea of money as a ‘thing’ that must be abstracted from social life in order (...) for it to be protected from manipulation by bank intermediaries and political authorities. The image is of a fully mechanized currency that operates over and above social life. In practice, however, the currency has generated a thriving community around its political ideals, relies on a high degree of social organization in order to be produced, has a discernible social structure, and is characterized by asymmetries of wealth and power that are not dissimilar from the mainstream financial system. Unwittingly, then, Bitcoin serves as a powerful demonstration of the relational character of money. (shrink)

This paper presents an 'internal' criticism of Winch's seminal 'Understanding a Primitive Society'. It distinguishes between two contrasting approaches to critical social understanding: (1) the metaphysical approach, central to the whole tradition of critical philosophy and critical social theory from Kant, through Marx to the Frankfurt School and contemporary theorists such as Habermas and Searle; (2) the descriptive approach, advocated by Winch, and which derives from Wittgenstein's critique of philosophical theory. It is argued, against a long tradition of 'critical theory' (...) depicting Wittgenstein's philosophy as irredeemably 'conservative', that the descriptive approach is perfectly apt for generating a critical understanding of central Western institutions. Rather than seeking to provide an explanatory theory through which to discern what allegedly is imperceptible to theoretically unaided perception (i.e. the metaphysical approach), the descriptive approach aims for a 'perspicuous presentation' of our everyday practices and institutions in such a way as to see their 'irrational' and 'alienating' dimensions. Winch's basic position in 'Understanding a Primitive Society' is endorsed, but it is argued that ultimately he fails in his descriptive intent. In place of the Christian prayer analogy that Winch invokes in order to make sense of Zande witchcraft, it is proposed that Western commodity production and exchange provide a more appropriate, instructive, and critical comparison. (shrink)

When I first came across Robert Nozick′s Philosophical Explanations I was struck by the purity of his justification of punishment. Most latter-day retributivists are crypto-utilitarians, claiming to find some sort of benefit in penalties, even if it is only symbolic. Nozick too sees punishment as symbolic, but not as having any necessary utility. Paradoxically, perhaps, he is one of the few retributivists who insists that it matters what the offender makes of his penalty. Even more interesting is the importance he (...) attaches to the analogy between retribution and revenge. Most retributivists are at pains to distance themselves from vengeance: but not Nozick. (shrink)

Slavery seems to us to be a paradigm of a morally wrong institutionalized practice. And yet for most of its millennia-long historical existence it was typically accepted as a natural, necessary, and inevitable feature of the social world. This widespread normative consensus was only challenged toward the end of the eighteenth century. Then, within a hundred years of the emergence of radical moral criticism of slavery, the existing practices had been dismantled and the institution itself “abolished.” How do we explain (...) such a “profound transformation in moral perception” (Davis 1975)? It may seem obvious that the moral agency and character of the leaders and activists of the abolition movement, their supporters, and their governmental representatives were the primary motors of change.That is to say, the various actors involved came to see, recognize, or acknowledge the true (morally evil) nature of slavery and were thereby motivated to act against it. This “commonsense,” “moral explanation” is endorsed by most of the philosophers who have reflected on the morality of slavery. But despite the intuitiveness of thinking that it was the moral agency of the actors, pitted against the evil and injustice of slavery, that brought about the latter’s downfall, I will endeavor to show that such thinking is inadequate both to the facts and to the explanatory desiderata. I contend that it was not ignor ance of the supposedly inherent moral status of slavery that maintained people’s complicity with it, but practical barriers to them conceiving it dispensable. (shrink)

What can computers do in principle? What are their inherent theoretical limitations? These are questions to which computer scientists must address themselves. The theoretical framework which enables such questions to be answered has been developed over the last fifty years from the idea of a computable function: intuitively a function whose values can be calculated in an effective or automatic way. This book is an introduction to computability theory (or recursion theory as it is traditionally known to mathematicians). Dr Cutland (...) begins with a mathematical characterisation of computable functions using a simple idealised computer (a register machine); after some comparison with other characterisations, he develops the mathematical theory, including a full discussion of non-computability and undecidability, and the theory of recursive and recursively enumerable sets. The later chapters provide an introduction to more advanced topics such as Gildel's incompleteness theorem, degrees of unsolvability, the Recursion theorems and the theory of complexity of computation. Computability is thus a branch of mathematics which is of relevance also to computer scientists and philosophers. Mathematics students with no prior knowledge of the subject and computer science students who wish to supplement their practical expertise with some theoretical background will find this book of use and interest. (shrink)

John Dewey stated that ‘[h]owever far apart philosophy and educational theory may later have become, in their beginnings they were strictly identical.' Dewey's ‘progressivism' in Democracy and Education rests on this communion. A self-reflective philosophical education by the community, about the community, for the community, would create the conditions for the advance of social justice. But new progressive ideas championing redistributive justice might appear to be in worryingly short supply. That is one reason, among many, why Philip Kitcher’s The Main (...) Enterprise of the World is to be welcomed. His rethinking about education amounts to a radical re-education of our thinking about social justice, seeking redistribution of wealth, reduction of privilege, and a redefinition of what is valuable for people and planet in regard to production, distribution, and consumption. I will summarize his book and offer critical thoughts on it relating to three themes: the relation of his proposed Deweyan Society to some current and powerful criticisms of Western rationality; his proposals for classrooms; and the extent to which its own pragmatic philosophical justifications are open to deeper philosophical and educational significance. (shrink)

Nigel Warburton is not betting that God exists….